Which works better on headaches – ibuprofen or acetaminophen?

If you’ve got a headache – take acetaminophen. 

The experts at the Cleveland Clinic put both to the test and acetaminophen, such as Tylenol, is the most effective at targeting that pain in the head. So when should you take ibuprofen, like Advil? It’s better for treating fevers, back and muscle aches, toothaches, earaches. 

Both remedies have risks, especially if you take them too often. If you’re going to need more than one dose, it’s a good idea to alternate the two because they are metabolized differently.